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Irfan Khan Movies, Photos and Filmography | Irfan Khan Indian Actor Photos Irfan Khan Movies, Photos and Filmography | Irfan Khan Indian Actor Photos , Irfan Khan last photo, hollywood movies, Irfan khan family photo with wife


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Irrfan Khan Wins Best Actor Award Full Video 2020 [MUST WATCH]

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Irrfan Khan, un actor indio que aportó versatilidad y estilo en películas exitosas y que tuvo papeles en filmes de Hollywood como "La vida de Pi" y "The Namesake​", murió el miércoles a los 54 años


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Irfan Khan's Last film Angrezi Medium like by everyone. Bollywood actor Irfan Khan passed away in Mumbai today. He was rushed to Kokilaben Ambani hospital


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TRIBUTE TO #IRFANKHAN 😔....--SHAH RUKH KHAN VS IRFAN KHAN FIGHT AT FILMFARE AWARDS😂😂 MUST WATCH

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イルファーン・カーン(ヒンディー語: इरफ़ान ख़ान, ウルドゥー語: عرفان خان‎, 英語: Irrfan Khan, 年1月7日 - 年4月29日)は、インドの俳優。 目次. 1 略歴; 2 出演作品; 3 脚注; 4 関連項目; 5 外部リンク. 略歴[編集]. ムスリム(


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/06/02 - このピンは、Irfan Khanさんが見つけました。あなたも Pinterest で自分だけのピンを見つけて保存しましょう!


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The Murders - Priyanka Chopra - Irfan Khan - New Bollywood Thriller Movie - Blockbuster - Full HD

fancj -cells are sensitive to DNA interstrand cross-linking ICL and replication fork stalling drugs. These findings have implications for therapeutic strategies relying on DNA cross-link sensitivity or heightened replication stress characteristic of cancer cells. AB - Fanconi Anemia FA is characterized by bone marrow failure, congenital abnormalities, and cancer.{/INSERTKEYS}{/PARAGRAPH} {PARAGRAPH}{INSERTKEYS}Of over 20 FA-linked genes, FANCJ uniquely encodes a DNA helicase and mutations are also associated with breast and ovarian cancer. We delineated the molecular defects of two FA patient-derived FANCJ helicase domain mutations. DNA binding and ATP hydrolysis was defective for both FANCJ-RC and FANCJ-HD, the latter showing greater reduction. FANCJ-RC was compromised in dimerization and helicase processivity, whereas DNA unwinding by FANCJ-HD was barely detectable. Live-cell imaging demonstrated a significantly compromised recruitment of FANCJ-RC to laser-induced DNA damage. Expression of FANCJ-RC or FANCJ-HD in fancj -cells failed to rescue cisplatin or mitomycin sensitivity. Thus, a minimal threshold of FANCJ catalytic activity is required to overcome replication stress induced by aphidicolin or telomestatin, or to repair bleomycin-induced DNA breakage.